Technical Research
The invention discloses a carrier-free nasal nanometer preparation brain targeted delivery system modified by chitooligosaccharide and a preparation method thereof.The preparation method of the brain targeted delivery system of the nasal nanometer preparation is also provided. The invention has a simple preparation method, which can improve the hydrophobicity, reduce toxicity and enhance the neuroprotective effect of small-molecule drugs. The preparation method of the brain targeted delivery system of the nasal nanometer preparation is also provided.There was no carrier, no biodegradation problem and no accumulation toxicity, the drug loading rate was up to more than 25%, and the drug was well absorbed through the membrane after chitosan oligosaccharide modification, and the drug was delivered into the brain with high targeting.
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Shi xuemin, Academician of Chinese Academy of Engineering and master of Chinese medicine
Yi-Ling Wu,Academician of Chinese Academy of Engineering、Yi-Ling pharmacy chairman
Li Dapeng,Academician of Chinese Academy of Engineering、Zhejiang kangte pharmaceutical co. LTD
Xiao-bo Sun,Director, institute of medicinal plants, Chinese academy of medical sciences
Xianzheng Zhang, Distinguished professor of changjiang scholars、National outstanding youth
Jian-Gang Shen , Professor, faculty of medicine, university of Hong Kong、Vice President, school of traditional Chinese medicine
Prof.Omid Farokhzad,Harvard University
Prof.Jinjun Shi,Harvard University